About Us Contact Us

Contact Us

Send 

Search

 

Evidence-Based Medicine and the Problem of Healthy Volunteers

Giulio Marchesini, Francesca Marchignoli, Salvatore Petta

Abstract

Healthy controls are subjects without the disease being studied but may have other conditions indirectly affecting outcome. In the present epidemics of obesity a few subjects with undiagnosed nonalcoholic fatty liver disease enter clinical studies as controls, producing biased results. Stricter selection criteria should be considered to prevent this risk.

Key words. Clinical trials., Control group., Liver Enzymes., NAFLD., Obesity.

Article Metrics

The Official Journal of the Mexican Association of Hepatology, the Latin-American Association for the Study of the Liver and the Canadian Association for the Study of the Liver

ALEH Hepatología CASL ACEF Médica Sur
Index Copernicus PubMed

© 2016 Annals of Hepatology. All rights reserved Privacy Policy