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Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

Claudio De Vito, Thomas Papathomas G., Federica Pedica, Pauline Kane, Ali Amir, Nigel Heaton, Alberto Quaglia

Abstract

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

Key words. Hepatocellular adenoma, Unicentric plasma cell type Castleman disease, Amyloidosis, Systemic symptoms, Interleukin-6

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The Official Journal of the Mexican Association of Hepatology, the Latin-American Association for the Study of the Liver and the Canadian Association for the Study of the Liver

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